Propyl vs. Pentyl Cannabinoids

Propyl vs. Pentyl Cannabinoids 

THC is a common cannabinoid that has “tails” of five carbon atoms. This defining feature classifies this cannabinoid as pentyl cannabinoidsOlivetolic acid is the precursor to pentyl cannabinoids. Olivetolic acid is used by the cannabis plant to create CBD. This CBG is then used to further make THC, CBD, and/or CBC. However, there is another class of cannabinoids that consists of three-carbon atom tails and they are called propyl cannabinoids. Certain cannabis plants in southern Africa has evolved a different precursor to CBG called divarinic acid. Divarinic acid is used by the plant to make a variation of CBD acid called CBGV acid. CBGV is then used by the plant to create the propyl cannabinoids: THCV, CBDV, or CBCV. 

Tetrahydrocannabivarinic Acid 

Tetrahydrocannabivarinic acid or THCVA is a far scarcer propyl form of THCA produced by Afghan and Pakistani and southern African cannabis cultivars. THCVA (as with all acidic cannabinoids, is converted to its bioactive neutral form, THCV, either through heat or time. The percentage in these cultivars of tetrahydrocannabivarinic acid (THCVA) rarely exceeds 2 percent in its dry weight form. 

Is THCV Psychoactive or Does It Just Modulate the Psychoactivity of THC? 

Controversy surrounds the question of whether THCV is psychoactive or simply just modulates the psychoactivity of THC. The reason for this is due to the fact that THCV’s psychoactivity hasn’t been studied since the early 1970’s. Historically speaking, THCV was thought to present around 25 percent of the potency of THC, however, more modern accounts claim that THCV does not produce psychoactivity on its own. The contradiction might have come from the dosage used, since THCV causes problems with the CB1 receptor at low doses, but will react with it at higher doses. THCV is thought to display a wide range of effects opposite to those of THC

THVC is similar to THC in terms of analgesic and anti-inflammatory, and similar to CBD with its anticonvulsant effects. There is actually interest in molecules which are similar to THCV as being a potential weight loss and increased energy expenditure in animal testing. 

Cannabidivarin (CBDVA) 

The propyl form of CBD is CBDVA. Recently, CBDVA has captured the attention of the cannabinoid medicine community due to its potential use as an anticonvulsant, alone as  
CBDVA and in combination with CBD

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